Gene Expression Literature Summary

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Nkx2-1  NK2 homeobox 1   (Synonyms: T/EBP, thyroid-specific enhancer-binding protein, thyroid transcription factor-1, tinman, Titf1, Ttf-1)
Results	Reference
1	J:173874 Andersson L, Westerlund J, Liang S, Carlsson T, Amendola E, Fagman H, Nilsson M, Role of EphA4 receptor signaling in thyroid development: regulation of folliculogenesis and propagation of the C-cell lineage. Endocrinology. 2011 Mar;152(3):1154-64
1	J:328140 Asgarian Z, Oliveira MG, Stryjewska A, Maragkos I, Rubin AN, Magno L, Pachnis V, Ghorbani M, Hiebert SW, Denaxa M, Kessaris N, MTG8 interacts with LHX6 to specify cortical interneuron subtype identity. Nat Commun. 2022 Sep 5;13(1):5217
1	J:174731 Bielle F, Marcos-Mondejar P, Keita M, Mailhes C, Verney C, Nguyen Ba-Charvet K, Tessier-Lavigne M, Lopez-Bendito G, Garel S, Slit2 activity in the migration of guidepost neurons shapes thalamic projections during development and evolution. Neuron. 2011 Mar 24;69(6):1085-98
1	J:276488 Bilodeau M, Shojaie S, Ackerley C, Post M, Rossant J, Identification of a proximal progenitor population from murine fetal lungs with clonogenic and multilineage differentiation potential. Stem Cell Reports. 2014 Oct 14;3(4):634-49
1	J:309393 Boggild S, Molgaard S, Glerup S, Nyengaard JR, Spatiotemporal patterns of sortilin and SorCS2 localization during organ development. BMC Cell Biol. 2016 Mar 10;17:8
1*	J:193583 Cai Y, Zhang Q, Wang C, Zhang Y, Ma T, Zhou X, Tian M, Rubenstein JL, Yang Z, Nuclear receptor COUP-TFII-expressing neocortical interneurons are derived from the medial and lateral/caudal ganglionic eminence and define specific subsets of mature interneurons. J Comp Neurol. 2013 Feb 1;521(2):479-97
1	J:171072 Carre A, Rachdi L, Tron E, Richard B, Castanet M, Schlumberger M, Bidart JM, Szinnai G, Polak M, Hes1 is required for appropriate morphogenesis and differentiation during mouse thyroid gland development. PLoS One. 2011;6(2):e16752
1	J:269807 Correa SM, Newstrom DW, Warne JP, Flandin P, Cheung CC, Lin-Moore AT, Pierce AA, Xu AW, Rubenstein JL, Ingraham HA, An estrogen-responsive module in the ventromedial hypothalamus selectively drives sex-specific activity in females. Cell Rep. 2015 Jan 6;10(1):62-74
1	J:306254 Crane-Smith Z, Schoenebeck J, Graham KA, Devenney PS, Rose L, Ditzell M, Anderson E, Thomson JI, Klenin N, Kurrasch DM, Lettice LA, Hill RE, A Highly Conserved Shh Enhancer Coordinates Hypothalamic and Craniofacial Development. Front Cell Dev Biol. 2021;9:595744
1*	J:322165 Cunningham JG, Scripter JD, Nti SA, Tucker ES, Early construction of the thalamocortical axon pathway requires c-Jun N-terminal kinase signaling within the ventral forebrain. Dev Dyn. 2022 Mar;251(3):459-480
1	J:197849 Deck M, Lokmane L, Chauvet S, Mailhes C, Keita M, Niquille M, Yoshida M, Yoshida Y, Lebrand C, Mann F, Grove EA, Garel S, Pathfinding of corticothalamic axons relies on a rendezvous with thalamic projections. Neuron. 2013 Feb 6;77(3):472-84
1	J:342610 Didier-Mathon H, Stoupa A, Kariyawasam D, Yde S, Cochant-Priollet B, Groussin L, Sebag F, Cagnard N, Nitschke P, Luton D, Polak M, Carre A, Borealin/CDCA8 deficiency alters thyroid development and results in papillary tumor-like structures. Front Endocrinol (Lausanne). 2023;14:1286747
1	J:269929 Elbert A, Vogt D, Watson A, Levy M, Jiang Y, Brule E, Rowland ME, Rubenstein J, Berube NG, CTCF Governs the Identity and Migration of MGE-Derived Cortical Interneurons. J Neurosci. 2019 Jan 2;39(1):177-192
1	J:104223 Fagman H, Andersson L, Nilsson M, The developing mouse thyroid: embryonic vessel contacts and parenchymal growth pattern during specification, budding, migration, and lobulation. Dev Dyn. 2006 Feb;235(2):444-55
1	J:117856 Fagman H, Liao J, Westerlund J, Andersson L, Morrow BE, Nilsson M, The 22q11 deletion syndrome candidate gene Tbx1 determines thyroid size and positioning. Hum Mol Genet. 2007 Feb 1;16(3):276-85
1	J:124892 Flames N, Pla R, Gelman DM, Rubenstein JL, Puelles L, Marin O, Delineation of multiple subpallial progenitor domains by the combinatorial expression of transcriptional codes. J Neurosci. 2007 Sep 5;27(36):9682-95
1	J:157830 Flandin P, Kimura S, Rubenstein JL, The progenitor zone of the ventral medial ganglionic eminence requires Nkx2-1 to generate most of the globus pallidus but few neocortical interneurons. J Neurosci. 2010 Feb 24;30(8):2812-23
1	J:153607 Hammond R, Blaess S, Abeliovich A, Sonic hedgehog is a chemoattractant for midbrain dopaminergic axons. PLoS One. 2009;4(9):e7007
1	J:200722 Hick AC, Delmarcelle AS, Bouquet M, Klotz S, Copetti T, Forez C, Van Der Smissen P, Sonveaux P, Collet JF, Feron O, Courtoy PJ, Pierreux CE, Reciprocal epithelial:endothelial paracrine interactions during thyroid development govern follicular organization and C-cells differentiation. Dev Biol. 2013 Sep 1;381(1):227-40
1	J:306316 Hou Y, Zhang Q, Liu H, Wu J, Shi Y, Qi Y, Shao M, Yang Z, Lu J, Wu Z, Gong L, He M, Topographical organization of mammillary neurogenesis and efferent projections in the mouse brain. Cell Rep. 2021 Feb 9;34(6):108712
1	J:224337 Jia Z, Guo Y, Tang Y, Xu Q, Li B, Wu Q, Regulation of the protocadherin Celsr3 gene and its role in globus pallidus development and connectivity. Mol Cell Biol. 2014 Oct;34(20):3895-910
1*	J:316194 Jimenez FR, Lewis JB, Belgique ST, Wood TT, Reynolds PR, Developmental lung expression and transcriptional regulation of claudin-6 by TTF-1, Gata-6, and FoxA2. Respir Res. 2014 Jun 26;15:70
1	J:239771 Johansson E, Andersson L, Ornros J, Carlsson T, Ingeson-Carlsson C, Liang S, Dahlberg J, Jansson S, Parrillo L, Zoppoli P, Barila GO, Altschuler DL, Padula D, Lickert H, Fagman H, Nilsson M, Revising the embryonic origin of thyroid C cells in mice and humans. Development. 2015 Oct 15;142(20):3519-28
1	J:317410 Johansson E, Liang S, Moccia C, Carlsson T, Andersson D, Fagman H, Nilsson M, Asynchrony of Apical Polarization, Luminogenesis, and Functional Differentiation in the Developing Thyroid Gland. Front Endocrinol (Lausanne). 2021;12:760541
1	J:226817 Kanatani S, Honda T, Aramaki M, Hayashi K, Kubo K, Ishida M, Tanaka DH, Kawauchi T, Sekine K, Kusuzawa S, Kawasaki T, Hirata T, Tabata H, Uhlen P, Nakajima K, The COUP-TFII/Neuropilin-2 is a molecular switch steering diencephalon-derived GABAergic neurons in the developing mouse brain. Proc Natl Acad Sci U S A. 2015 Sep 8;112(36):E4985-94
1	J:221510 Kariyawasam D, Rachdi L, Carre A, Martin M, Houlier M, Janel N, Delabar JM, Scharfmann R, Polak M, DYRK1A BAC transgenic mouse: a new model of thyroid dysgenesis in Down syndrome. Endocrinology. 2015 Mar;156(3):1171-80
1	J:292005 Kim E, Jiang M, Huang H, Zhang Y, Tjota N, Gao X, Robert J, Gilmore N, Gan L, Que J, Isl1 Regulation of Nkx2.1 in the Early Foregut Epithelium Is Required for Trachea-Esophageal Separation and Lung Lobation. Dev Cell. 2019 Dec 16;51(6):675-683.e4
1*	J:108240 Kusakabe T, Hoshi N, Kimura S, Origin of the ultimobranchial body cyst: T/ebp/Nkx2.1 expression is required for development and fusion of the ultimobranchial body to the thyroid. Dev Dyn. 2006 May;235(5):1300-9
1	J:237344 Lee B, Lee S, Lee SK, Lee JW, The LIM-homeobox transcription factor Isl1 plays crucial roles in the development of multiple arcuate nucleus neurons. Development. 2016 Oct 15;143(20):3763-3773
1	J:308018 Li E, Ustiyan V, Wen B, Kalin GT, Whitsett JA, Kalin TV, Kalinichenko VV, Blastocyst complementation reveals that NKX2-1 establishes the proximal-peripheral boundary of the airway epithelium. Dev Dyn. 2021 Jul;250(7):1001-1020
1	J:293339 Liang S, Johansson E, Barila G, Altschuler DL, Fagman H, Nilsson M, A branching morphogenesis program governs embryonic growth of the thyroid gland. Development. 2018 Jan 25;145(2):dev146829
1	J:74531 Liu C, Glasser SW, Wan H, Whitsett JA, GATA-6 and Thyroid Transcription Factor-1 Directly Interact and Regulate Surfactant Protein-C Gene Expression. J Biol Chem. 2002 Feb 8;277(6):4519-25
1	J:144312 Lopez-Bendito G, Cautinat A, Sanchez JA, Bielle F, Flames N, Garratt AN, Talmage DA, Role LW, Charnay P, Marin O, Garel S, Tangential neuronal migration controls axon guidance: a role for neuregulin-1 in thalamocortical axon navigation. Cell. 2006 Apr 7;125(1):127-42
1	J:193919 Lu F, Kar D, Gruenig N, Zhang ZW, Cousins N, Rodgers HM, Swindell EC, Jamrich M, Schuurmans C, Mathers PH, Kurrasch DM, Rax is a selector gene for mediobasal hypothalamic cell types. J Neurosci. 2013 Jan 2;33(1):259-72
1	J:206284 Lu KM, Evans SM, Hirano S, Liu FC, Dual role for Islet-1 in promoting striatonigral and repressing striatopallidal genetic programs to specify striatonigral cell identity. Proc Natl Acad Sci U S A. 2014 Jan 7;111(1):E168-77
1	J:219800 Lungova V, Verheyden JM, Herriges J, Sun X, Thibeault SL, Ontogeny of the mouse vocal fold epithelium. Dev Biol. 2015 Mar 15;399(2):263-82
1	J:199986 Ma T, Zhang Q, Cai Y, You Y, Rubenstein JL, Yang Z, A subpopulation of dorsal lateral/caudal ganglionic eminence-derived neocortical interneurons expresses the transcription factor Sp8. Cereb Cortex. 2012 Sep;22(9):2120-30
1	J:330767 Magno L, Asgarian Z, Apanaviciute M, Milner Y, Bengoa-Vergniory N, Rubin AN, Kessaris N, Fate mapping reveals mixed embryonic origin and unique developmental codes of mouse forebrain septal neurons. Commun Biol. 2022 Oct 27;5(1):1137
1	J:254523 Magno L, Barry C, Schmidt-Hieber C, Theodotou P, Hausser M, Kessaris N, NKX2-1 Is Required in the Embryonic Septum for Cholinergic System Development, Learning, and Memory. Cell Rep. 2017 Aug 15;20(7):1572-1584
1	J:322231 Malwade S, Gasthaus J, Bellardita C, Andelic M, Moric B, Korshunova I, Kiehn O, Vasistha NA, Khodosevich K, Identification of Vulnerable Interneuron Subtypes in 15q13.3 Microdeletion Syndrome Using Single-Cell Transcriptomics. Biol Psychiatry. 2022 Apr 15;91(8):727-739
1	J:293992 Mancia Leon WR, Spatazza J, Rakela B, Chatterjee A, Pande V, Maniatis T, Hasenstaub AR, Stryker MP, Alvarez-Buylla A, Clustered gamma-protocadherins regulate cortical interneuron programmed cell death. Elife. 2020 Jul 7;9:e55374
1	J:210221 Mandai K, Reimert DV, Ginty DD, Linx mediates interaxonal interactions and formation of the internal capsule. Neuron. 2014 Jul 2;83(1):93-103
1	J:177127 McCarthy DM, Zhang X, Darnell SB, Sangrey GR, Yanagawa Y, Sadri-Vakili G, Bhide PG, Cocaine alters BDNF expression and neuronal migration in the embryonic mouse forebrain. J Neurosci. 2011 Sep 21;31(38):13400-11
1	J:304361 Mitsogiannis MD, Pancho A, Aerts T, Sachse SM, Vanlaer R, Noterdaeme L, Schmucker D, Seuntjens E, Subtle Roles of Down Syndrome Cell Adhesion Molecules in Embryonic Forebrain Development and Neuronal Migration. Front Cell Dev Biol. 2020;8:624181
1	J:226687 Morello F, Prasad AA, Rehberg K, Vieira de Sa R, Anton-Bolanos N, Leyva-Diaz E, Adolfs Y, Tissir F, Lopez-Bendito G, Pasterkamp RJ, Frizzled3 Controls Axonal Polarity and Intermediate Target Entry during Striatal Pathway Development. J Neurosci. 2015 Oct 21;35(42):14205-19
1	J:242687 Nandi S, Gutin G, Blackwood CA, Kamatkar NG, Lee KW, Fishell G, Wang F, Goldfarb M, Hebert JM, FGF-Dependent, Context-Driven Role for FRS Adapters in the Early Telencephalon. J Neurosci. 2017 Jun 07;37(23):5690-5698
1*	J:113028 Niimi T, Kurotani R, Kimura S, Kitagawa Y, Identification and expression of alternative splice variants of the mouse Ppp1r3b gene in lung epithelial cells. Biochem Biophys Res Commun. 2006 Oct 20;349(2):588-96
1	J:145460 Nobrega-Pereira S, Kessaris N, Du T, Kimura S, Anderson SA, Marin O, Postmitotic Nkx2-1 controls the migration of telencephalic interneurons by direct repression of guidance receptors. Neuron. 2008 Sep 11;59(5):733-45
1	J:332133 Nunnelly LF, Campbell M, Lee DI, Dummer P, Gu G, Menon V, Au E, St18 specifies globus pallidus projection neuron identity in MGE lineage. Nat Commun. 2022 Dec 14;13(1):7735
1	J:167713 Okubo T, Kawamura A, Takahashi J, Yagi H, Morishima M, Matsuoka R, Takada S, Ripply3, a Tbx1 repressor, is required for development of the pharyngeal apparatus and its derivatives in mice. Development. 2011 Jan;138(2):339-48
1*	J:157005 Park J, Zhang JJ, Moro A, Kushida M, Wegner M, Kim PC, Regulation of Sox9 by Sonic Hedgehog (Shh) is essential for patterning and formation of tracheal cartilage. Dev Dyn. 2010 Feb;239(2):514-26
1	J:80538 Postiglione MP, Parlato R, Rodriguez-Mallon A, Rosica A, Mithbaokar P, Maresca M, Marians RC, Davies TF, Zannini MS, De Felice M, Di Lauro R, Role of the thyroid-stimulating hormone receptor signaling in development and differentiation of the thyroid gland. Proc Natl Acad Sci U S A. 2002 Nov 26;99(24):15462-7
1*	J:262512 Raju CS, Spatazza J, Stanco A, Larimer P, Sorrells SF, Kelley KW, Nicholas CR, Paredes MF, Lui JH, Hasenstaub AR, Kriegstein AR, Alvarez-Buylla A, Rubenstein JL, Oldham MC, Secretagogin is Expressed by Developing Neocortical GABAergic Neurons in Humans but not Mice and Increases Neurite Arbor Size and Complexity. Cereb Cortex. 2018 Jun 1;28(6):1946-1958
1	J:202984 Rockich BE, Hrycaj SM, Shih HP, Nagy MS, Ferguson MA, Kopp JL, Sander M, Wellik DM, Spence JR, Sox9 plays multiple roles in the lung epithelium during branching morphogenesis. Proc Natl Acad Sci U S A. 2013 Nov 19;110(47):E4456-64
1	J:343283 Russell NX, Burra K, Shah RM, Bottasso-Arias N, Mohanakrishnan M, Snowball J, Ediga HH, Madala SK, Sinner D, Wnt signaling regulates ion channel expression to promote smooth muscle and cartilage formation in developing mouse trachea. Am J Physiol Lung Cell Mol Physiol. 2023 Dec 1;325(6):L788-L802
1	J:338817 Schoultz E, Liang S, Carlsson T, Filges S, Stahlberg A, Fagman H, Wiel C, Sayin V, Nilsson M, Tissue specificity of oncogenic BRAF targeted to lung and thyroid through a shared lineage factor. iScience. 2023 Jul 21;26(7):107071
1	J:228291 Shinmyo Y, Asrafuzzaman Riyadh M, Ahmed G, Bin Naser I, Hossain M, Takebayashi H, Kawasaki H, Ohta K, Tanaka H, Draxin from neocortical neurons controls the guidance of thalamocortical projections into the neocortex. Nat Commun. 2015;6:10232
1*	J:225740 Snowball J, Ambalavanan M, Whitsett J, Sinner D, Endodermal Wnt signaling is required for tracheal cartilage formation. Dev Biol. 2015 Sep 1;405(1):56-70
1	J:290119 Soleilhavoup C, Travaglio M, Patrick K, Garcao P, Boobalan E, Adolfs Y, Spriggs RV, Moles-Garcia E, Dhiraj D, Oosterveen T, Ferri SL, Abel T, Brodkin ES, Pasterkamp RJ, Brooks BP, Panman L, Nolz1 expression is required in dopaminergic axon guidance and striatal innervation. Nat Commun. 2020 Jun 19;11(1):3111
1	J:295090 Stoupa A, Adam F, Kariyawasam D, Strassel C, Gawade S, Szinnai G, Kauskot A, Lasne D, Janke C, Natarajan K, Schmitt A, Bole-Feysot C, Nitschke P, Leger J, Jabot-Hanin F, Tores F, Michel A, Munnich A, Besmond C, Scharfmann R, Lanza F, Borgel D, Polak M, Carre A, TUBB1 mutations cause thyroid dysgenesis associated with abnormal platelet physiology. EMBO Mol Med. 2018 Dec;10(12)
1	J:308676 Talley MJ, Nardini D, Qin S, Prada CE, Ehrman LA, Waclaw RR, A role for sustained MAPK activity in the mouse ventral telencephalon. Dev Biol. 2021 Aug;476:137-147
1	J:302725 Tao G, Li Z, Wen Y, Song X, Wei S, Du H, Yang Z, Xu Z, You Y, Transcription Factors Sp8 and Sp9 Regulate Medial Ganglionic Eminence-Derived Cortical Interneuron Migration. Front Mol Neurosci. 2019;12:75
1	J:255379 Tinterri A, Deck M, Keita M, Mailhes C, Rubin AN, Kessaris N, Lokmane L, Bielle F, Garel S, Tangential migration of corridor guidepost neurons contributes to anxiety circuits. J Comp Neurol. 2018 Feb 15;526(3):397-411
1	J:127418 Uemura M, Nakao S, Suzuki ST, Takeichi M, Hirano S, OL-Protocadherin is essential for growth of striatal axons and thalamocortical projections. Nat Neurosci. 2007 Sep;10(9):1151-9
1	J:222557 Villar-Cervino V, Kappeler C, Nobrega-Pereira S, Henkemeyer M, Rago L, Nieto MA, Marin O, Molecular Mechanisms Controlling the Migration of Striatal Interneurons. J Neurosci. 2015 Jun 10;35(23):8718-29
1	J:192502 Wei B, Huang Z, He S, Sun C, You Y, Liu F, Yang Z, The onion skin-like organization of the septum arises from multiple embryonic origins to form multiple adult neuronal fates. Neuroscience. 2012 Oct 11;222:110-23
1	J:175765 Woo J, Miletich I, Kim BM, Sharpe PT, Shivdasani RA, Barx1-mediated inhibition of Wnt signaling in the mouse thoracic foregut controls tracheo-esophageal septation and epithelial differentiation. PLoS One. 2011;6(7):e22493
1	J:324465 Yu D, Li T, Delpech JC, Zhu B, Kishore P, Koshi T, Luo R, Pratt KJB, Popova G, Nowakowski TJ, Villeda SA, Piao X, Microglial GPR56 is the molecular target of maternal immune activation-induced parvalbumin-positive interneuron deficits. Sci Adv. 2022 May 6;8(18):eabm2545
1*	J:165724 Yu S, Poe B, Schwarz M, Elliot SA, Albertine KH, Fenton S, Garg V, Moon AM, Fetal and postnatal lung defects reveal a novel and required role for Fgf8 in lung development. Dev Biol. 2010 Nov 1;347(1):92-108